Nieves Lopez-Barrera, MD
Medical Doctor with 18+ years of progressive experience in the United States as a medical director, medical monitor, senior clinical coordinator, and research manager in both device and pharmaceutical settings. Focused on NASH, ALD, PBC, HIV, COVID-19, and oncology research, working extensively on therapy initiatives for research for a cure. Outstanding team leader and player. Developed (and implemented) protocols, standards of practice, rules/regulations. Expert in assessing and caring for physical and emotional needs of wide-ranging patient populations. Remain calm and focused in the most urgent of circumstances. Personable with all patients and staff; go out of the way to ensure their comfort. Naturally meticulous, never take shortcuts, continually prepared for all scenarios.
Professional Experience
Clinical Development Director / Medical Monitor
Areas of specialty: NASH, ALD
- Lead Clinical Program Management: Oversee strategic and clinical plans for liver disease studies, ensuring regulatory compliance and study delivery.
- Collaborate with Cross-Functional Teams: Work with internal and external stakeholders to optimize study designs and timelines, addressing patient needs and business goals.
- Support Regulatory and Strategic Initiatives: Facilitate regulatory interactions, contribute to strategic projects, and mentor Clinical Sciences staff.
Associate Medical Director
Areas of specialty: NASH, PBC, HIV, COVID-19, Oncology
- Cross-functional team membership and people management.
- Clinical Development Planning.
- Regulatory submissions.
- CRO Management: Function as the medical monitor of clinical studies and work closely with the CRO to achieve study timelines and goals.
Research Manager
- Managed and created site SOPs, CAPAs, note to files, sponsor discrepancies, and IRB submissions.
- Managed and created site source documents, sponsor-specific source documents, and trainings.
- Collaborated with patient subjects on phase I, II, & III efficacy of controlled drugs.
- Supervised clinical trials; orchestrated patient care and administrative duties.
Senior Clinical Research Coordinator / Outreach Coordinator
Areas of specialty: Parkinson, other movement disorders
- Educated patients regarding proper procedures and information needed pre-trial.
- Monitored patients for safety concerns and side effects. Prepared patients for procedures.
- Assessed patient health and safety on experimental medications. Reported SAEs and collected medical records.
Research Assistant Professor
Implemented the clinical trial SPRINT (Systolic Blood Pressure Intervention Trial). Responsible for all research-related activities including physical assessment, phlebotomy, blood pressure management, administration of questionnaires, and collection and transmission of clinical data and specimens.
Research Study Coordinator
Planned activities of a portfolio of patient-oriented research studies and coordinated the workflow for a team of physicians, nurses, psychometricians, research assistants, and phlebotomists, as needed for clinical and biological data collection. Managed collection, completion, and organization of research data ensuring integrity and completeness of data.
Heart Failure Unit – Pharmacology Therapies
Department of Internal Medicine, Hospital Clínico San Carlos. Madrid (Spain) • 2000 – 2005
Collaboration in Project e-CARDS and e-NEA CARDS
Editorial Científica Digital. Entorno Digital de Comunicación S.L. • 2004
Internal Medicine Specialist
Hospital Mediterráneo. Almería (Spain) • 06/2019 - 09/2019
Internal Medicine Specialist
Belen Polyclinic. Cusco (Peru) • 08/2018
Emergency Department Physician
Hospital Severo Ochoa. Leganés, Madrid (Spain) • 01/2006 - 07/2006
Emergency Department Physician
Fundación-Hospital Alcorcón. Madrid (Spain) • 08/2005 - 12/2005
Internal Medicine Residency
Hospital Clínico San Carlos. Madrid (Spain) • 2000 – 2005
Formative rotations: Cardiology, Intensive Care, Neurology, Rheumatology, Radiodiagnostic, Palliative Care, Nephrology, Anesthesia & Resuscitation. International Observership at Infectious Diseases and AIDS Department, Jackson Memorial Medical Center, Miami (FL, USA), 10 weeks in 2005.
Education
MD, Medicine and Surgery
Internal Medicine Residency
Department of Internal Medicine IV. Formative rotations: Cardiology, Intensive Care, Neurology, Rheumatology, Radiodiagnostic, Palliative Care, Nephrology, Anesthesia & Resuscitation. International Observership at Infectious Diseases and AIDS Department, Jackson Memorial Medical Center, Miami (FL, USA).
Clinical Research Coordinator Certification
Expertise & Skills
Signature Strengths
Certifications
- Collaborative Institutional Training Initiative (CITI Program)
- ICH Good Clinical Practice
- Data Privacy Training & Research Aspects of HIPAA
- NIH: Protecting Human Research Participants
- IV / Blood Draw & CPR / Basic Life Support
- ECG, Holter Certification & Fibroscan operator training
- Transporting Dangerous Goods (IATA/ICAO, Category A/B)
- Annual Bloodborne Pathogens
- Hazard Communication Awareness Training
Publications & Research Output
A proven track record of contributing to medical science and education.
Racial differences in prevalence and severity of non-alcoholic fatty liver disease.
World J Hepatol. 2021 Jul 27;13(7):763-773. doi: 10.4254/wjh.v13.i7.763.
Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study.
Ann Intern Med. 2018 Nov 6;169(9):610-618.
Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes.
N Engl J Med. 2017 Aug 24;377(8):733-744.
Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial.
J Clin Hypertens (Greenwich). 2017 Feb;19(2):116-125.
Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.
Neurology. 2016 Feb 26.
Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial.
J Gerontol A Biol Sci Med Sci. 2016 Jan 11.
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
N Engl J Med. 2015 Nov 26;373(22):2103-16.
The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT).
Clin Trials. 2014 Oct;11(5):532-46.
Acute Infectious Meningitis.
Tiempos Médicos. Rev de Educación Médica Continuada. 2005 Sep, N621, Pág.7.
Urinary Tract Infection in women.
Tiempos Médicos. Rev de Educación Médica Continuada. 2005 Sep, N621, Pág.35.
Progressive Multifocal Leukoencephalopathy cases during nine years in Hospital Clínico San Carlos.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.39.
Visceral Leishmaniasis: Clinical Data, epidemiology and diagnosis.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.141.
Pharmacologic Therapies in a Heart Failure Unit.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.183.
Clinical evolution of a Heart failure unit's patients.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.183.
Description of a Heart failure unit's working in an internal medicine department.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.183.
Left recurrent laryngeal nerve paralysis in a patient with apical pleuritis.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.216.
Causes of changed diagnosis in the internal medicine ward.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.351.
Concordance between diagnosis made in the emergency room and the ones made in the internal medicine ward.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.352.
Descending aortitis: an uncommon form of presentation of giant cell arteritis.
Revista Clínica Española. Vol 204, Suppl 1, Sep 2004, pág.395.
How to start investigating anaemia without an obvious cause?.
European Journal of Internal Medicine. Vol 14, Suppl 1, 2003, pg.64.
Risk factors for peripheral embolism in atrial fibrillation.
European Journal of Internal Medicine. Vol 14, Suppl 1, 2003, pg.99.
Infectious colitis by non-common microorganisms.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.51-52.
Prolonged fever and cervical spine pain.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.51.
Evolutionary factors in aspiration pneumonias.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.52.
Differences by sex in aspiration pneumonia.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.52.
Odinofagia and epigastralgia in a 28 year-old man with HIV.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.57.
Leucocytoclastic vasculitis in a solid tumor.
Anales de Medicina Interna. Nº Extr, Oct 2003, pg.67-68.
Hypertension as a cardiovascular risk factor.
Tiempos Médicos. Rev de Educación Médica Continuada. 2003 Enero, N596, Pág.7.
Diabetes and cardiovascular effects.
Tiempos Médicos. Rev de Educación Médica Continuada. 2003 Enero, N596, Pág.29.
What are the clinical differences between men and women in SAOS diagnosis?.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.25.
Types of clinical presentation in tuberculosis infection in an internal medicine department.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.141.
Peripheral embolism y atrial fibrillation: predisposed factors and treatment importance.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.218.
Etiologic study of syncopes.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.231.
Etiology of anaemia without an obvious cause in an internal medicine hospital.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.261.
Do we use appropriate doses of ACE Inhibitors?.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.263.
Thyroid dysfunction and amiodarone.
Revista Clínica Española. Vol 202, Suppl 1, Nov 2002, pg.318.
EEN Study of lung and cardiac pathology.
Archivos de Bronconeumología. Vol 38, Suppl 2, Jun 2002, pg.108.
Disabling back pain in a 53 year-old woman.
Revista Clínica Española. 2002 Mayo, Vol 202, N5, pag.291.
Urinary Tract Infections.
Tiempos Médicos. Rev de Educación Médica Continuada. 2001 Noviembre, N584, pág.7.
Acute Infectious Gastroenteritis.
Tiempos Médicos. Rev de Educación Médica Continuada. 2001 Noviembre, N584, pág.35.
Syncope and electrocardiographic alterations in young patients.
Anales de Medicina Interna. Nº Extr, Nov 2001, pg.40.
Young patient with tetraparesis in an emergency service.
Anales de Medicina Interna. Nº Extr, Nov 2001, pg.71-72.
Clinical presentation of abdominal tuberculosis infection in an internal medicine department.
Anales de Medicina Interna. Nº Extr, Nov 2001, pg.64.
Presentation of lung cancer in young patients.
Anales de Medicina Interna. Nº Extr, Nov 2001, pg.30.
GSK4532990 pharmacokinetic–pharmacodynamic (PK–PD) modelling supports quarterly and monthly siRNA dosing for MASH in the HORIZON phase 2b study.
Liver Meeting, EASL Congress, 2025, Amsterdam (Netherlands).
Digital arteriography as an important diagnostic test in Sneddon syndrome.
5th EFIM, Paris (France), Aug–Sep 2005.
Postcardiotomy syndrome: A case that illustrates the process to arrive to a correct diagnosis.
5th EFIM, Paris (France), Aug–Sep 2005.
Malaria infection in a 40-year-old woman as an example of growing tropical diseases in our country (Spain).
5th EFIM, Paris (France), Aug–Sep 2005.
Progressive Multifocal Leukoencephalopathy cases during nine years in Hospital Clínico San Carlos of Madrid.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Visceral Leishmaniasis: Clinical Data, epidemiology and diagnosis.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Pharmacological Therapies in a heart failure unit.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Clinical evolution of patients in a heart failure unit.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Description of a Heart failure unit's working in an internal medicine department.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Left recurrent laryngeal nerve paralysis in a patient with apical pleuritis.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Causes of changed diagnosis in the internal medicine ward.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Concordance between diagnosis made in the emergency room and the ones made in the internal medicine ward.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
Descending aortitis: an uncommon form of presentation of giant cell arteritis.
27th World Congress of Internal Medicine, Granada (Spain), Sep–Oct 2004.
How to start investigating anaemia without an obvious cause?.
4th Congress EFIM, Berlin (Germany), Sep 2003.
Risk factors for peripheral embolism in atrial fibrillation.
4th Congress EFIM, Berlin (Germany), Sep 2003.
Infectious colitis by non-common microorganisms.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Prolonged fever and cervical spine pain.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Evolutionary factors in aspiration pneumonias.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Differences by sex in aspiration pneumonia.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Odinofagia and epigastralgia in a 28 year-old man with HIV.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Leucocytoclastic vasculitis in a solid tumor.
IX Congreso Soc. Med. Interna Madrid-Castilla La Mancha, Cuenca, Oct 2003.
Patient with cervical spine pain and fever.
IX Reunión Soc. Madrid-Castilla La Mancha Med. Interna, U. de Alcalá, Madrid, Jan 2003.
What are the clinical differences between men and women in SAOS diagnosis?.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Types of clinical presentation in tuberculosis infection in an internal medicine department.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Peripheral embolism y atrial fibrillation: predisposed factors and treatment importance.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Etiologic study of syncopes.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Etiology of anaemia without an obvious cause in an internal medicine hospital.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Do we use appropriate doses of medicine?.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
Thyroid dysfunction and amiodarone.
XXV Congreso Nacional de la SEMI, Madrid, Nov 2002.
EEN Study of lung and cardiac pathology.
XXXV Congreso Nacional de la SEPAR, Maspalomas, Gran Canaria, Jun 2002.
Syncope and electrocardiographic alterations in young patients.
VIII Congreso Soc. Madrid-Castilla La Mancha Med. Interna, Ciudad Real, Nov 2001.
A young patient with tetraparesis in an emergency service.
VIII Congreso Soc. Madrid-Castilla La Mancha Med. Interna, Ciudad Real, Nov 2001.
Clinical presentation of abdominal tuberculosis infection in an internal medicine department.
VIII Congreso Soc. Madrid-Castilla La Mancha Med. Interna, Ciudad Real, Nov 2001.
Presentation of lung cancer in young patients.
VIII Congreso Soc. Madrid-Castilla La Mancha Med. Interna, Ciudad Real, Nov 2001.
Published Book
Editorial Edimat Libros S.A. 2003.
Book Chapters – Emergency Medicine, First Aid and Life Support Handbook
Escuela Madrileña de Socorrismo y Formación Sanitaria. S.Coop.
- Conscience Disorders
- Respiratory Emergency
- Acute Chest Pain
- Acute Abdominal Pain
- Ophthalmology Emergency
- Allergic Reactions & Anaphylaxis
- Pharmacologic Intoxication
- Ethanol Intoxication
- Drugs Overdose
Course of Dislipemias
medifusion.com, January 2005.
Clinical Cases Library about Hyperlipemia in Specialty Care
PharmaConsult Services S.A., October 2004.
Vice-president
Centro San Bonifacio (Chicago, IL) • 07/2008 – 01/2010
Mission is to promote personal and collective self-development within the immigrant Hispanic community through concrete projects based on real needs related to health, education, solidarity and human rights.
Founder and Facilitator, "Sin Aviso" Support Group
Rush Medical Center – Memory Clinic (Chicago, IL) • 2007 – 2010
Collaborated with medical personnel, family members, and caregivers to serve Alzheimer patients. Established critical Early On-Set educational support program for Spanish-speaking community with zero budget, generating funding through successful fundraisers and events.
Founder and Health Care Provider
Community Health (Chicago) • 06/2007 – 01/2010
Founded the Depression Support Group in Spanish. CommunityHealth is Illinois' largest volunteer-based medical facility providing free care to the uninsured and underserved, funded solely through private donations.
Courses & Continuing Education
- Illinois Latino Nonprofit Leadership Academy Latino Policy Forum, 3 workshops (9 days total), 2012
- Financial Management of Clinical Trials: What Every Coordinator Should Know ACRP Webinar, Oct 2008
- ESL Advanced Grammar Review Rush University Medical Center, Oct 2008
- ELI 250 Electrocardiograph Training Quintiles ECG Services, Oct 2008
- ADAS-Cog Certification i3 Research, Jul 2008
- MMSE Certification i3 Research, Jul 2008
- ADAS Certification Alzheimer's Disease Cooperative Study, Jul 2008
- Cantab Training Certification Cambridge University (UK), Jul 2008
- INF 4.5 CRC Modules Phase Forward, Jun 2008
- Pfizer Impala Training Jun 2008
- Electrocardiograph Training Biomedical System Corporation, Apr 2008
- The Protection of Human Subjects in Research Rush University Medical Center, Mar 2008
- HIPAA Training Rush University Medical Center, Mar 2008
- Phlebotomy Certification Medtexx Medical Corporation, Feb 2008
- Introduction to Epic Rush University Medical Center, Jan 2008
- English as a Second Language Rush University Medical Center, Nov 2007
- Hazardous Materials and Dangerous Goods Transportation Training Rush University Medical Center, Nov 2007
- Tutor Training for English as a Second Language Literacy Works, Chicago, Jun 2007
- American English Pronunciation Rush University Medical Center, May 2007
- 2007 Biological Therapeutics for Autoimmune Diseases Symposium Northwestern University, Chicago, Apr 2007
- Charts and Graphs in Excel and PowerPoint Rush University Medical Center, Apr 2007
- Giving and Receiving Feedback Rush University Medical Center, Mar 2007
- Talking about Performance Rush University Medical Center, Mar 2007
- Business-Writing, Grammar and Proofreading II Rush University Medical Center, Mar 2007
2005
- HIV/AIDS 2005 Pictorial; CROI Update 2005; Transitioning Care of the HIV Patient; Gene Expression Patterns in HIV and KSHV Infection; Importance of STDs for Society; Disseminated Intravascular Coagulation (DIC) and AIDS; Persistence of Drug-Resistance Mutations in Acute HIV Infection School of Medicine, University of Miami
- 12th Symposium about Digestive Diseases Hospital Clínico San Carlos, Madrid
- 7th Heart Failure Annual Meeting Internal Medicine Spanish Society, Santiago de Compostela
- Third Course of Clinical Electrocardiography Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid
- Pharmacokinetic Interactions in Statin Therapy; Contact Dermatitis; Allergic Diseases Prevalence; Minor Surgery in General Practice; Extra-esophageal Manifestations of GERD; Asthma Etiology; GERD; Bronchiectasis Formación Médica Continuada, Colegio Médicos de Madrid
2004
- 6th Heart Failure Annual Meeting Internal Medicine Spanish Society, León (Spain)
- Cardiac Arrhythmias Diagnosis and Treatment Course (20h, 3.7 credits) C. de Formación Continuada, Madrid
- 10th Symposium about Oncogenes and Cancer UCM, Madrid
- Depression: Diagnosis (0.8 credits) & Treatment (1.2 credits) Comisión Nacional de Formación Continuada
- 11th Symposium about Digestive Diseases Hospital Clínico San Carlos, Madrid
- 11th Congress of Infectious Diseases and Clinical Microbiology Bilbao (Spain)
- 27th World Congress of Internal Medicine ISIM, Granada (Spain)
2003
- 5th Heart Failure Annual Meeting Internal Medicine Spanish Society, Córdoba
- Dislipemias: Diagnosis and Treatment (60h, 4.1 credits) Comisión Nacional de Formación Continuada
- Cardiac Arrhythmias Treatment (20h) Cardiac Electrophysiology Dept., Hospital Clínico San Carlos
- First Practice Course of Cardiology Up-to-Date (12h) Cardiology Spanish Society, Madrid
- 11th Congress of Madrid-Castilla La Mancha Internal Medicine Society Cuenca (Spain)
2002
- Pain Treatment Up-to-Date and Improvement Course (5.5 credits) Comisión Nacional de Formación Continuada
- 25th National Congress of Internal Medicine Spanish Society Madrid
- 6th EPOC and Antimicrobial Agents Meeting Quimiotherapy Spanish Society, Madrid
- 4th Antimicrobial Agents Course: Clinical Practice (24h) Microbiology Dept., UCM, Madrid
2001
- Nosocomial Infectious Diseases Prevalence Study in Spanish Hospitals (EPINE) Public Health and Infection Control Spanish Society
2000
- MIR Asturias Intensive Course (650h) Medical Association of Asturias
- Discussions about Medical Ethics and Deontology Medicine Faculty, Universidad de Granada, 1999
- 2nd Medical-Legal National Symposium (30h) Instituto de Ciencias Médicas y Jurídicas, Granada, 1998
- First Medical-Legal National Symposium: Medicine in Criminal Law (30h) Instituto de Ciencias Médicas y Jurídicas, Granada, 1997
- Emergency Module III: HIV+ Patient in Emergency Department (14h) ICU, Hospital Virgen de las Nieves, Granada, 1997
- First Conference of Intensive Health and Agriculture Consejería de Salud, Poniente Hospital, El Ejido (Almería), 1997
- Emergency Module I: Community Infections and Emergency Medicine (12h) ICU, Hospital Virgen de las Nieves, Granada, 1996
- Emergency Practice Course (20h) Colegio Mayor Fray Luis de Granada, U. de Granada, 1995
- Cardiopulmonary Basic Resuscitation and First Aids (32h) Training Centre of Spanish Cruz Roja, Granada, 1995